If Spore freezes on the splash screen when you start it up, with one running process and one non-responding one, then all you have to do is*:
- Browse to the SPORE application in Finder
- Right-click the spore application and select “Show Package Contents”
- In the new finder window browser into the the MacOS directory and move the “cider_noui” file away to another location, like your desktop.
- Launch Spore again and keep your fingers crossed.
I found this piece of information through MacRumors.